Is Prime by MangoRx as effective as TRT? Yes, Prime by MangoRx is designed to be an effective alternative to traditional testosterone replacement therapy (TRT). Prime increases free testosterone by 2x: This means higher Free Testosterone levels without increasing Total Testosterone. It’s a promising concept compared to other TRT treatments, offering the effects of higher Testosterone without the associated side effects. Prime also mimics the body’s natural diurnal rhythm: The male body naturally produces Testosterone during sleep, peaking in the morning, and returning to baseline at night. Taking Prime orally at the right times allows for this natural system to be followed, creating a new form of testosterone treatment that closely mirrors the body’s natural rhythm.